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IntEnz EC 1.1.1.27 - L-lactate dehydrogenase

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Examples: 1.1.1.1, alcohol%, alpha-glucosidase



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EC 1 -
Oxidoreductases



EC
1.1 -
Acting on the CH-OH group of donors



EC
1.1.1

- With NAD+ or NADP+ as acceptor







EC 1.1.1.27

- L-lactate dehydrogenase










 




IntEnz view










ENZYME view


























XML





IntEnz Enzyme Nomenclature
EC 1.1.1.27


















Names




Accepted name:

L-lactate dehydrogenase





Other
names:


L(+)-nLDH


L-(+)-lactate dehydrogenase


L-lactic acid dehydrogenase


L-lactic dehydrogenase




NAD-lactate dehydrogenase




lactate dehydrogenase




lactate dehydrogenase NAD-dependent




lactic acid dehydrogenase




lactic dehydrogenase








Systematic name:

(S)-lactate:NAD+ oxidoreductase


















Reaction








  • 23444


    [IUBMB]














































































    (S)-lactate



    (S)-lactate





    Name origin:


    UniProt - CHECKED (C)










    CHEBI:16651









    Formula:
    C3H5O3

    Charge: -1






    ChEBI compound status: CHECKED (C)










    (No structure available)




    +







































    NAD+



    NAD(+)





    Name origin:


    UniProt - CHECKED (C)










    CHEBI:57540









    Formula:
    C21H26N7O14P2

    Charge: -1






    ChEBI compound status: CHECKED (C)










    (No structure available)









    =
























































    H+



    H(+)





    Name origin:


    UniProt - CHECKED (C)










    CHEBI:15378









    Formula:
    H

    Charge: 1






    ChEBI compound status: CHECKED (C)










    (No structure available)




    +







































    NADH



    NADH





    Name origin:


    UniProt - CHECKED (C)










    CHEBI:57945









    Formula:
    C21H27N7O14P2

    Charge: -2






    ChEBI compound status: CHECKED (C)










    (No structure available)




    +







































    pyruvate



    pyruvate





    Name origin:


    UniProt - CHECKED (C)










    CHEBI:15361









    Formula:
    C3H3O3

    Charge: -1






    ChEBI compound status: CHECKED (C)










    (No structure available)
















Comments:







Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme.



















Links to other databases




Enzymes and pathways:






















NC-IUBMB





,



















BRENDA





,



















ERGO





,



















ExplorEnz





,



















ENZYME@ExPASy





,



















KEGG





,



















MetaCyc





,



















NIST 74





,



















UniPathway









Protein domains and families:



















PROSITE:PDOC00062













Structural data:






















CSA





,



















EC2PDB










Gene Ontology:




















GO:0004459












CAS Registry Number:

9001-60-9









UniProtKB/Swiss-Prot:

(311)

[show]
[UniProt]








References



  1. Dennis, D. and Kaplan, N.O.


    D and L-lactic acid dehydrogenase in Lactobacillus plantarum.




    J. Biol. Chem.
    235:
    810-818

    (1960).









  2. Everse, J. and Kaplan, N.O.

    Lactate dehydrogenases: structure and function.




    Adv. Enzymol. Relat. Subj. Biochem.
    37:
    61-133

    (1973).

    [PMID: 4146647]









  3. Holbrook, J.J., Liljas, A., Steindel, S.J. and Rossmann, M.G.

    Lactate dehydrogenase.






    In: Boyer, P.D. (Ed.)

    The Enzymes, 3rd ed. vol. 11, Academic Press, New York, 1975,
    191-292








  4. Schär, H.-P. and Zuber, H.

    Structure and function of L-lactate dehydrogenases from thermophilic and mesophilic bacteria. I) Isolation and characterization of lactate dehydrogenases from thermophilic and mesophilic bacilli.




    Hoppe-Seyler's Z. Physiol. Chem.
    360:
    795-807

    (1979).

    [PMID: 114469]








[EC 1.1.1.27 created 1961]


















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