_EC 1.1.1.27 L-lactate dehydrogenase.
 133 PDB entries  





















EC 1.-.-.- Oxidoreductases.
[11,653 PDB entries]











EC 1.1.-.- Acting on the CH-OH group of donors.
[2,419 PDB entries]












EC 1.1.1.- With NAD(+) or NADP(+) as acceptor.
[2,176 PDB entries]























EC 1.1.1.27
L-lactate dehydrogenase.
[133 PDB entries]
   






1a5z





















Reaction:

(S)-lactate + NAD(+) = pyruvate + Nadh.
 











(S)-lactate

+


NAD(+)

=


pyruvate

+


NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Other name(s):

L-lactic acid dehydrogenase.
L-lactic dehydrogenase.
Comments:

Also oxidizes other (S)-2-hydroxymonocarboxylic acids.
NADP(+) acts, more slowly, with the animal, but not the bacterial,
enzyme.
Links:
 
[IntEnz]  
[ExPASy]  
[KEGG]  


There are 133 PDB entries in enzyme class E.C.1.1.1.27

























































































































































































































































































































































































































  PDB code
Protein

1a5z








Lactate dehydrogenase from thermotoga maritima (tmldh)


Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(312 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1ceq






Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase.


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(304 residues)
CATH domains:
3.40.50.720
3.90.110.10

1cet






Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase.


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(305 residues)
CATH domains:
3.40.50.720
3.90.110.10

1ez4








Crystal structure of non-allosteric l-lactate dehydrogenase from lactobacillus pentosus at 2.3 angstrom resolution


Source: Lactobacillus pentosus. Organism_taxid: 1589. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1hyh








Crystal structure of l-2-hydroxyisocaproate dehydrogenase from lactobacillus confusus at 2.2 angstroms resolution-an example of strong asymmetry between subunits


Source: Weissella confusa. Organism_taxid: 1583. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: german collection of microorganisms (dsm) number dsm 20196, cell plasm


Chains:
A, B, C, D
(297 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1i0z








Human heart l-lactate dehydrogenase h chain, ternary complex with nadh and oxamate


Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Gene: ldhb. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.


Chains:
A, B
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1i10








Human muscle l-lactate dehydrogenase m chain, ternary complex with nadh and oxamate


Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Gene: ldha. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.


Chains:
A, B, C, D, E, F, G, H
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1ldb






Structure determination and refinement of bacillus stearothermophilus lactate dehydrogenase


Source: Geobacillus stearothermophilus. Organism_taxid: 1422


Chains:
A, B, C, D
(294 residues)
CATH domains:
3.40.50.720
3.90.110.10

1ldg








Plasmodium falciparum l-lactate dehydrogenase complexed with nadh and oxamate


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1ldm








Refined crystal structure of dogfish m4 apo-lactate dehydrogenase


Source: Squalus acanthias. Spiny dogfish. Organism_taxid: 7797


Chain:
A
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1ldn








Structure of a ternary complex of an allosteric lactate dehydrogenase from bacillus stearothermophilus at 2.5 angstroms resolution


Source: Geobacillus stearothermophilus. Organism_taxid: 1422


Chains:
A, B, C, D, E, F, G, H
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1llc






Structure determination of the allosteric l-lactate dehydrogenase from lactobacillus casei at 3.0 angstroms resolution


Source: Lactobacillus casei. Organism_taxid: 1582


Chain:
A
(321 residues)
CATH domains:
3.40.50.720
3.90.110.10

1lld








Molecular basis of allosteric activation of bacterial l-lactate dehydrogenase


Source: Bifidobacterium longum subsp. Longum. Organism_taxid: 1679. Strain: subsp. Longum.


Chains:
A, B
(313 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1lth








T and r states in the crystals of bacterial l-lactate dehydrogenase reveal the mechanism for allosteric control


Source: Bifidobacterium longum subsp. Longum. Organism_taxid: 1679. Strain: subsp. Longum. Gene: bifidobacterium longum ldh gene. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
T, R
(313 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1oc4








Lactate dehydrogenase from plasmodium berghei


Source: Plasmodium berghei. Organism_taxid: 5821. Strain: anka. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1pze






T.Gondii ldh1 apo form


Source: Toxoplasma gondii. Organism_taxid: 508771. Strain: me49. Gene: lactate dehydrogenase. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(323 residues)
CATH domains:
3.40.50.720
3.90.110.10

1pzf








T.Gondii ldh1 ternary complex with apad+ and oxalate


Source: Toxoplasma gondii. Organism_taxid: 5811. Gene: lactate dehydrogenase. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.00% similar to
enzyme reactant (S)-lactate

 
Het Group A3D
is 95.00% similar to
enzyme reactant NAD(+)

1pzg








T.Gondii ldh1 complexed with apad and sulfate at 1.6 angstroms


Source: Toxoplasma gondii. Organism_taxid: 508771. Strain: me49. Gene: ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group A3D
is 95.56% similar to
enzyme reactant NAD(+)

1pzh








T.Gondii ldh1 ternary complex with NAD and oxalate


Source: Toxoplasma gondii. Organism_taxid: 508771. Strain: me49. Gene: lactate dehydrogenase (ldh1). Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1sov






Toxoplasma gondii bradyzoite-specific ldh (ldh2) apo form


Source: Toxoplasma gondii. Organism_taxid: 5811. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10

1sow








T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxalate


Source: Toxoplasma gondii. Organism_taxid: 5811. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(322 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1t24








Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXQ
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1t25








Plasmodium falciparum lactate dehydrogenase complexed with nadh and 3- hydroxyisoxazole-4-carboxylic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group GAG
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1t26








Plasmodium falciparum lactate dehydrogenase complexed with nadh and 4- hydroxy-1,2,5-thiadiazole-3-carboxylic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group GBD
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1t2c








Plasmodium falciparum lactate dehydrogenase complexed with nadh


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1t2d








Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and oxalate


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1t2e








Plasmodium falciparum lactate dehydrogenase s245a, a327p mutant complexed with nadh and oxamate


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1t2f








Human b lactate dehydrogenase complexed with NAD+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldhb. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXQ
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1u4o








Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedicarboxylic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(309 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MPD
is 40.00% similar to
enzyme reactant (S)-lactate

1u4s






Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedisulphonic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10

1u5a






Plasmodium falciparum lactate dehydrogenase complexed with 3,5- dihydroxy-2-naphthoic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: lactate dehydrogenase. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(306 residues)
CATH domains:
3.40.50.720
3.90.110.10

1u5c








Plasmodium falciparum lactate dehydrogenase complexed with 3,7- dihydroxynaphthalene-2-carboxylic acid and NAD+


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(305 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1v6a






Crystal structure of l-lactate dehydrogenase from cyprinus carpio


Source: Cyprinus carpio. Common carp. Organism_taxid: 7962. Tissue: skeletal muscle


Chains:
A, B
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10

1vbi








Crystal structure of type 2 malate/lactate dehydrogenase from thermus thermophilus hb8


Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.


Chain:
A
(340 residues)
CATH domains:
1.10.1530.10
3.30.1370.60





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1x0a








Crystal structure of type ii malate/lactate dehydrogenase from thermus thermophilus hb8


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.


Chain:
A
(344 residues)
CATH domains:
1.10.1530.10
3.30.1370.60





Bound ligand:  
Het Group FMT
is 50.00% similar to
enzyme reactant (S)-lactate

1xiv








Plasmodium falciparum lactate dehydrogenase complexed with 2-(4- chloro-[hydroxy(methoxy)methyl]cyclohexylamino)ethane-1,1,2-triol


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

1y6j






L-lactate dehydrogenase from clostridium thermocellum cth-1135


Source: Clostridium thermocellum. Organism_taxid: 1515. Atcc: 27405. Gene: cth-1135. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(289 residues)
CATH domains:
3.40.50.720
3.90.110.10

2a92








Crystal structure of lactate dehydrogenase from plasmodium vivax: complex with nadh


Source: Plasmodium vivax. Malaria parasite p. Vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

2a94








Structure of plasmodium falciparum lactate dehydrogenase complexed to apadh.


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group AP0
is 95.56% similar to
enzyme reactant NAD(+)

2aa3








Crystal structure of plasmodium vivax lactate dehydrogenase complex with apadh


Source: Plasmodium vivax. Malaria parasite p. Vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group AP0
is 95.56% similar to
enzyme reactant NAD(+)

2e37








Structure of tt0471 protein from thermus thermophilus


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.


Chains:
A, B, C, D, E, F, G, H
(308 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

2fn7








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (lactic acid) and cofactor (b- nicotinamide adenine dinucleotide)


Source: Cryptosporidium parvum. Organism_taxid: 5807. Gene: ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group LAC
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme product NADH

2ldb








Structure determination and refinement of bacillus stearothermophilus lactate dehydrogenase


Source: Geobacillus stearothermophilus. Organism_taxid: 1422


Chains:
A, B, C, D
(301 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

2ldx






Characterization of the antigenic sites on the refined 3- angstroms resolution structure of mouse testicular lactate dehydrogenase c4


Source: Mus musculus. House mouse. Organism_taxid: 10090


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10

2v65






Apo ldh from the psychrophilE C. Gunnari


Source: Champsocephalus gunnari. Mackerel icefish. Organism_taxid: 52237. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B
(326 residues)
CATH domains:
3.40.50.720
3.90.110.10

2v6b






Crystal structure of lactate dehydrogenase from deinococcus radiodurans (apo form)


Source: Deinococcus radiodurans. Organism_taxid: 1299. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(274 residues)
CATH domains:
3.40.50.720
3.90.110.10

2v6m






Crystal structure of lactate dehydrogenase from thermus thermophilus hb8 (apo form)


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10

2v7p








Crystal structure of lactate dehydrogenase from thermus thermophilus hb8 (holo form)


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

2x8l








Plasmodium falciparum lactate dehydrogenase apo structure


Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: malaria parasite


Chain:
A
(311 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

2xxb








Penta-mutant of thermus thermophilus lactate dehydrogenase, complex with amp


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group AMP
is 52.00% similar to
enzyme reactant NAD(+)

2xxj








Penta mutant of lactate dehydrogenase from thermus thermophilus, ternary complex


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: dh5alpha.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

2zqy






T-state structure of allosteric l-lactate dehydrogenase from lactobacillus casei


Source: Lactobacillus casei. Organism_taxid: 1582. Strain: iam 12473. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(305 residues)
CATH domains:
3.40.50.720
3.90.110.10

2zqz






R-state structure of allosteric l-lactate dehydrogenase from lactobacillus casei


Source: Lactobacillus casei. Organism_taxid: 1582. Strain: iam 12473. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D, E, F
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10

3czm








T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxq


Source: Toxoplasma gondii. Organism_taxid: 5811. Gene: lactate dehydrogenase. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(322 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXQ
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3d0o






Crystal structure of lactate dehydrogenase from staphylococcus aureus


Source: Staphylococcus aureus. Organism_taxid: 93062. Strain: col. Gene: ldh1, sacol0222. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(309 residues)
CATH domains:
3.40.50.720
3.90.110.10

3d4p








Crystal structure of lactate dehydrogenase from staphylococcus aureus complexed with NAD and pyruvate


Source: Staphylococcus aureus subsp. Aureus col. Organism_taxid: 93062. Gene: ldh1, sacol0222. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3h3f








Rabbit muscle l-lactate dehydrogenase in complex with nadh and oxamate


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Other_details: muscle


Chains:
A, B, C, D, E, F, G, H
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

3h3j








Crystal structure of lactate dehydrogenase mutant (a85r) from staphylococcus aureus complexed with NAD and pyruvate


Source: Staphylococcus aureus subsp. Aureus col. Organism_taxid: 93062. Gene: ldh1, sacol0222. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(313 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3ldh








A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes


Source: Squalus acanthias. Spiny dogfish. Organism_taxid: 7797


Chain:
A
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3om9








T. Gondii bradyzoite-specific ldh (ldh1) in complex with NAD and oxq


Source: Toxoplasma gondii. Organism_taxid: 5811. Gene: lactate dehydrogenase, tggt1_115280. Expressed in: escherichia coli. Expression_system_taxid: 511693.


Chains:
A, B, C, D
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXQ
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3pqd








Crystal structure of l-lactate dehydrogenase from bacillus subtilis complexed with fbp and NAD+


Source: Bacillus subtilis. Organism_taxid: 1423. Gene: ldh, lcte, bsu03050. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B, C, D, E, F, G, H
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3pqe






Crystal structure of l-lactate dehydrogenase from bacillus subtilis with h171c mutation


Source: Bacillus subtilis. Organism_taxid: 1423. Gene: ldh, lcte, bsu03050. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B, C, D
(314 residues)
CATH domains:
3.40.50.720
3.90.110.10

3pqf








Crystal structure of l-lactate dehydrogenase from bacillus subtilis mutation h171c complexed with NAD+


Source: Bacillus subtilis. Organism_taxid: 1423. Gene: ldh, lcte, bsu03050. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B, C, D
(314 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3vku






Penta mutant of lactobacillus casei lactate dehydrogenase


Source: Lactobacillus casei. Organism_taxid: 1582. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F
(290 residues)
CATH domains:
3.40.50.720
3.90.110.10

3vkv






Complex structure of lactobacillus casei lactate dehydrogenase with fructose-1,6-bisphosphate


Source: Lactobacillus casei. Organism_taxid: 1582. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10

3vpf








Complex structure of lactobacillus casei lactate dehydrogenase penta mutant with pyruvate


Source: Lactobacillus casei. Organism_taxid: 1582. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F
(306 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

3vpg








L-lactate dehydrogenase from thermus caldophilus gk24


Source: Thermus caldophilus. Organism_taxid: 272. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

3vph








L-lactate dehydrogenase from thermus caldophilus gk24 complexed with oxamate, nadh and fbp


Source: Thermus caldophilus. Organism_taxid: 272. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3wsv








Crystal structure of minor l-lactate dehydrogenase from enterococcus mundtii in the ligands-unbound form


Source: Enterococcus mundtii. Organism_taxid: 53346. Strain: 15-1a. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(312 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

3wsw








Crystal structure of minor l-lactate dehydrogenase from enterococcus mundtii in the ligands-bound form


Source: Enterococcus mundtii. Organism_taxid: 53346. Strain: 15-1a. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3zh2






Structure of plasmodium falciparum lactate dehydrogenase in complex with a DNA aptamer


Source: Plasmodium falciparum. Organism_taxid: 36329. Strain: 3d7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630


Chains:
A, B, C, D
(314 residues)
CATH domains:
3.40.50.720
3.90.110.10

3zzn








5-mutant (r79w, r151a, e279a, e299a,e313a) lactate-dehydrogenase from thermus thermophillus


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 668369.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group ADP
is 61.36% similar to
enzyme reactant NAD(+)

4a73






Single point mutant of thermus thermophilus lactate dehydrogenase


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 668369.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10

4aj1








Rat ldha in complex with n-(2-(methylamino)-1,3- benzothiazol-6-yl)acetamide


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4aj2








Rat ldha in complex with 5-(2-chlorophenyl)-1h-tetrazole


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(327 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4aj4








Rat ldha in complex with 4-((2-allylsulfanyl-1,3-benzothizol-6-yl) amino)-4-oxo-butanoic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MLI
is 62.50% similar to
enzyme reactant (S)-lactate

4aje








Rat ldha in complex with 2-(4-bromophenoxy)propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(327 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group 2B4
is 40.00% similar to
enzyme reactant (S)-lactate

4ajh








Rat ldha in complex with n-(2-methyl-1,3-benzothiazol-6-yl)-3-ureido- propanamide and 2-(4-bromophenoxy)propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group 2B4
is 40.00% similar to
enzyme reactant (S)-lactate

4aji






Rat ldha in complex with 2-((3,4-dimethoxyphenyl)methyl)) propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(327 residues)
CATH domains:
3.40.50.720
3.90.110.10

4ajj








Rat ldha in complex with 2-((3,4-dimethoxyphenyl)methyl)) propanedioic acid and n-(2-methyl-1,3-benzothiazol-6-yl)-3- ureido-propanamide


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MLI
is 62.50% similar to
enzyme reactant (S)-lactate

4ajk








Rat ldha in complex with n-(2-(methylamino)-1,3-benzothiazol-6-yl) acetamide


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MLI
is 62.50% similar to
enzyme reactant (S)-lactate

4ajl








Rat ldha in complex with 3-(ethylcarbamoylamino)-n-(2-methyl-1,3- benzothiazol-6-yl)propanamide


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4ajn








Rat ldha in complex with 2-((4-(2-((3-((2-methyl-1,3- benzothiazol-6-yl)amino)-3-oxo-propyl)carbamoylamino)ethyl) phenyl)methyl)propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4ajo








Rat ldha in complex with 2-((4-(4-((3-((2-methyl-1,3- benzothiazol-6yl)amino)-3-oxo-propyl)amino)-4-oxo-butyl) phenyl)methyl)propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4ajp








Human ldha in complex with 2-((4-(4-((3-((2-methyl-1,3- benzothiazol-6yl)amino)-3-oxo-propyl)amino)-4-oxo-butyl) phenyl)methyl)propanedioic acid


Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4al4








Rat ldha in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)3-oxo-propyl)carbamoylamino)ethoxy) phenyl) methylpropanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4b7u








Plasmodium falciparum l-lactate dehydrogenase complexed with bicine


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MPD
is 40.00% similar to
enzyme reactant (S)-lactate

4i8x






Crystal structure of rabbit ldha in complex with ap27460


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D, E, F, G, H
(321 residues)
CATH domains:
3.40.50.720
3.90.110.10

4i9h






Crystal structure of rabbit ldha in complex with ap28669


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D, E, F, G, H
(325 residues)
CATH domains:
3.40.50.720
3.90.110.10

4i9n






Crystal structure of rabbit ldha in complex with ap28161 and ap28122


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D, E, F, G, H
(324 residues)
CATH domains:
3.40.50.720
3.90.110.10

4i9u






Crystal structure of rabbit ldha in complex with a fragment inhibitor ap26256


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D, E, F, G, H
(323 residues)
CATH domains:
3.40.50.720
3.90.110.10

4jnk








Lactate dehydrogenase a in complex with inhibitor compound 22


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(326 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group LAC
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4l4r






Structural characterisation of the apo-form of human lactate dehydrogenase m isozyme


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, H
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10

4l4s








Structural characterisation of the nadh binary complex of human lactate dehydrogenase m isozyme


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
H, A
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4lmr






Crystal structure of l-lactate dehydrogenase from bacillus cereus atcc 14579, nysgrc target 029452


Source: Bacillus cereus. Organism_taxid: 226900. Strain: atcc 14579. Gene: bc_1924, ldh, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B
(312 residues)
CATH domains:
3.40.50.720
3.90.110.10

4ln1






Crystal structure of l-lactate dehydrogenase from bacillus cereus atcc 14579 complexed with calcium, nysgrc target 029452


Source: Bacillus cereus. Organism_taxid: 226900. Strain: atcc 14579. Gene: bc_1924, ldh, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B, C, D
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10

4m1q








Crystal structure of l-lactate dehydrogenase from bacillus selenitireducens mls10, nysgrc target 029814.


Source: Bacillus selenitireducens. Organism_taxid: 439292. Strain: mls10. Gene: ldh, bsel_2311. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B
(312 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MPD
is 40.00% similar to
enzyme reactant (S)-lactate

4m49








Lactate dehydrogenase a in complex with a substituted pyrazine inhibitor compound 18


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group LAC
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4nd1








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with cofactor (b-nicotinamide adenine dinucleotide) and inhibitor (oxamic acid)


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

4nd2








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (pyruvic acid) and cofactor analog (3-acetylpyridine adenine dinucleotide)


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group A3D
is 95.56% similar to
enzyme reactant NAD(+)

4nd3








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (l-lactic acid) and cofactor (b- nicotinamide adenine dinucleotide)


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group 2OP
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

4nd4








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (pyruvic acid) and cofactor (b- nicotinamide adenine dinucleotide)


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

4nd5






Crystal structure of the lactate dehydrogenase from cryptosporidium parvum


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(302 residues)
CATH domains:
3.40.50.720
3.90.110.10

4ojn








Crystal structure of human muscle l-lactate dehydrogenase


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F, G, H
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4okn








Crystal structure of human muscle l-lactate dehydrogenase, ternary complex with nadh and oxalate


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F, G, H
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4plz








Crystal structure of plasmodium falciparum lactate dehydrogenase mutant w107fa.


Source: Plasmodium falciparum. Organism_taxid: 5833. Gene: ldh-p, ldh, ldh. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chain:
A
(302 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4qo7








Lactate dehydrogenase a in complex with substituted 3-hydroxy-2- mercaptocyclohex-2-enone compound 7


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group 2OP
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4qo8








Lactate dehydrogenase a in complex with substituted 3-hydroxy-2- mercaptocyclohex-2-enone compound 104


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group LAC
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4qsm






Crystal structure of human muscle l-lactate dehydrogenase in complex with inhibitor 2, 3-[7-(2,4-dimethoxypyrimidin-5-yl)-3- sulfamoylquinolin-4-yl]aminobenzoic acid


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F, G, H
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10

4qt0






Crystal structure of human muscle l-lactate dehydrogenase in complex with inhibitor 1, 3-[3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl) quinolin-4-yl]aminobenzoic acid


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F, G, H
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10

4r68








Lactate dehydrogenase in complex with inhibitor compound 31


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4r69








Lactate dehydrogenase in complex with inhibitor compound 13


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(325 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4rls








Lactate dehydrogenase in complex with inhibitor compound 47


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group 2OP
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4uul






Apo trichomonas vaginalis lactate dehydrogenase l91r


Source: Trichomonas vaginalis. Organism_taxid: 5722. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(334 residues)

4uum






Apo trichomonas vaginalis lactate dehydrogenase


Source: Trichomonas vaginalis. Organism_taxid: 5722. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B
(334 residues)

4uun








Trichomonas vaginalis lactate dehydrogenase in complex with nadh


Source: Trichomonas vaginalis. Organism_taxid: 5722. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(335 residues)





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4zvv








Lactate dehydrogenase a in complex with a trisubstituted piperidine-2, 4-dione inhibitor gne-140


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

5a1t








Trichomonas vaginalis lactate dehydrogenase in complex with nadh and oxamate


Source: Trichomonas vaginalis. Organism_taxid: 5722. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B
(331 residues)







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

5es3








Co-crystal structure of ldh liganded with oxamate


Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: ldha, ldh-1, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, C, E, F, D, H, B, G
(328 residues)





Bound ligand:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

5hru






Crystal structure of plasmodium vivax ldh in complex with a DNA aptamer called pl1


Source: Plasmodium vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Phylica emirnensis. Organism_taxid: 178505


Chains:
A, B
(305 residues)

5hs4






Plasmdoium vivax lactate dehydrogenase


Source: Plasmodium vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(301 residues)

5hto






Crystal structure of plasmodium vivax ldh in complex with a DNA aptamer called pl1 (tetrameric ldh in an asymmetric unit)


Source: Plasmodium vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 5855


Chains:
A, B, D, E
(302 residues)

5ixs








Lactate dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6r)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6- (thiophen-3-yl)-5,6-dihydropyridin-2(1h)-one


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(327 residues)





Bound ligand:  
Het Group TXD
corresponds to
enzyme reactant NAD(+)

5ixy








Lactate dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~s)-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4- oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

5k0z






Cryo-em structure of lactate dehydrogenase (ldh) in inhibitor-bound state


Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ldhb. Expressed in: bacteria. Expression_system_taxid: 2


Chains:
A, B, C, D
(317 residues)

5kkc








L-lactate dehydrogenase from rabbit muscle with the inhibitor 6dhnad


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D
(328 residues)





Bound ligand:  
Het Group 6V0
corresponds to
enzyme reactant NAD(+)

5ldh








Structure of the active ternary complex of pig heart lactate dehydrogenase with s-lac-NAD at 2.7 angstroms resolution


Source: Sus scrofa. Pig. Organism_taxid: 9823


Chains:
A, B
(334 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group CIT
is 46.15% similar to
enzyme reactant (S)-lactate

 
Het Group LNC
is 86.27% similar to
enzyme product NADH

5nqb








Rabbit muscle l-lactate dehydrogenase in complex with malonate


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Gene: ldha. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)





Bound ligand:  
Het Group MLI
is 62.50% similar to
enzyme reactant (S)-lactate

5nqq








Rabbit muscle l-lactate dehydrogenase in complex with nadh and oxaloacetate


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Gene: ldha. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)







Bound ligands:  
Het Group OAA
is 66.67% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

6ldh






Refined crystal structure of dogfish m4 apo-lactate dehydrogenase


Source: Squalus acanthias. Spiny dogfish. Organism_taxid: 7797


Chain:
A
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10

8ldh








Refined crystal structure of dogfish m4 apo-lactate dehydrogenase


Source: Squalus acanthias. Spiny dogfish. Organism_taxid: 7797


Chain:
A
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group CIT
is 46.15% similar to
enzyme reactant (S)-lactate

9ldb








Design and synthesis of new enzymes based on the lactate dehydrogenase framework


Source: Sus scrofa. Pig. Organism_taxid: 9823


Chains:
A, B
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

9ldt








Design and synthesis of new enzymes based on the lactate dehydrogenase framework


Source: Sus scrofa. Pig. Organism_taxid: 9823


Chains:
A, B
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)
-

Popular posts from this blog

Canceling a color specificationRandomly assigning color to Graphics3D objects?Default color for Filling in Mathematica 9Coloring specific elements of sets with a prime modified order in an array plotHow to pick a color differing significantly from the colors already in a given color list?Detection of the text colorColor numbers based on their valueCan color schemes for use with ColorData include opacity specification?My dynamic color schemes

Image
Would it be easier to colonise a living world or a dead world? Postal services in Italy - Poste Italiane vs. Friendpost vs. GPS What is /dev/null and why can't I use hx on it? Why are engines with carburetors hard to start in cold weather? How to make a gift without seeming creepy? Without exposing his identity, did Roy help his parents with money so that they can afford to stay in their home? Does the Creighton Method of Natural Family Planning have a failure rate of 3.2% or less? How do I break the broom in Untitled Goose Game? Had there been instances of national states banning harmful imports before the mid-19th C Opium Wars? D&D Monsters and Copyright Is sleeping on the groud in cold weather better than on an air mattress? Transiting through Switzerland by coach with lots of cash quadratic equations on 2 by 2 matrices Always Lubricate Skewers? I pay for a service, but I miss the broadcast Iron-age tools, is there a way to extract heavy metals ...
Read more

Invision Community Contents History See also References External links Navigation menuProprietaryinvisioncommunity.comIPS Community ForumsIPS Community Forumsthis blog entry"License Changes, IP.Board 3.4, and the Future""Interview -- Matt Mecham of Ibforums""CEO Invision Power Board, Matt Mecham Is a Liar, Thief!"IPB License Explanation 1.3, 1.3.1, 2.0, and 2.1ArchivedSecurity Fixes, Updates And Enhancements For IPB 1.3.1Archived"New Demo Accounts - Invision Power Services"the original"New Default Skin"the original"Invision Power Board 3.0.0 and Applications Released"the original"Archived copy"the original"Perpetual licenses being done away with""Release Notes - Invision Power Services""Introducing: IPS Community Suite 4!"Invision Community Release Notes

Image
Internet forum softwarePHP software Internet communityPHPMySQLdatabase management systemInternet forumCharles WarnerMatt MechamJarvis Entertainment GroupIkonboardInvisionFreeAjaxIPS Community ForumsIPS Community Forumsthis blog entry Invision Community From Wikipedia, the free encyclopedia Jump to navigation Jump to search Invision Community Developer(s) Invision Power Services Stable release 4.4.6 / August 19, 2019 ; 34 days ago  ( 2019-08-19 ) Platform PHP / MySQL Type Forum software License Proprietary Website invisioncommunity.com Invision Community (previously known as IPS Community Suite ) is primarily an Internet community software produced by Invision Power Services, Inc. It is written in PHP and uses MySQL as a database management system. Invision Power Services sell applications that each can be bought and installed separately in addition to the Suite, the most widely known being the Internet forum software Invision Power Boar...
Read more

François Viète Contents Biography Work and thought Bibliography See also Notes Further reading External links Navigation menup. 21Google Bookspp. 75–77Google BooksDe thou (from University of Saint Andrews)ArchivedGoogle BooksGoogle BooksGoogle BooksGoogle booksGoogle Bookscc-parthenay.frL'histoire universelle (fr)Universal History (en)ArchivedAdsabs.harvard.eduPagesperso-orange.frArchive.orgChikara Sasaki. Descartes' mathematical thought p.259Google BooksGoogle BooksGoogle Bookspp. 152 and onwardGoogle BooksGoogle BooksScribd.comGoogle Books1257-7979Google BooksGoogle BooksGoogle BooksGoogle BooksGoogle BooksGoogle BooksGallica.bnf.frGoogle BooksGoogle Books"François Viète"Francois Viète: Father of Modern Algebraic NotationThe Lawyer and the GamblerAbout TarporleySite de Jean-Paul GuichardL'algèbre nouvelle"About the Harmonicon"cb120511976(data)1188044800000 0001 0913 5903n82164680ola2013766880073431702w6vt1sb70287374827140948071409480

Image
1540 births1603 deathsPeople from Fontenay-le-ComtePre-19th-century cryptographers16th-century French mathematiciansAlgebraistsFrench cryptographersUniversity of Poitiers alumni LatinSeigneurFrenchmathematicianprivy councillorHenry IIIHenry IVFontenay-le-ComteVendéeLa RochelleLe BusseauBarnabé BrissonmagistrateCatholic League of France.FranciscanPoitiersBachelor of LawsKing Francis I of FranceMary, Queen of ScotsHuguenotLyonJacques of Savoy, 2nd Duke of NemoursMouchampsVendéeCatherine de ParthenayastronomytrigonometryStevinKeplerGiordano BrunoCharles IX of FranceParthenayColignyCondéQueen Jeanne d’Albret of NavarreHenry IV of FranceJacques de ThouSt. Bartholomew's Day massacreAdmiral ColignyJacques, Duke of NemoursParliament of BrittanyRennesHenri, duc de Rohanmaître des requêtesHenry of NavarreHenry III of FranceFontenayBeauvoir-sur-MerNew AlgebraJoseph Juste ScaligerToursSpanishcipherWars of ReligionAloysius LiliusChristopher ClaviusAdriaan van Room...
Read more