_EC 1.1.1.27 L-lactate dehydrogenase.
 133 PDB entries  





















EC 1.-.-.- Oxidoreductases.
[11,653 PDB entries]











EC 1.1.-.- Acting on the CH-OH group of donors.
[2,419 PDB entries]












EC 1.1.1.- With NAD(+) or NADP(+) as acceptor.
[2,176 PDB entries]























EC 1.1.1.27
L-lactate dehydrogenase.
[133 PDB entries]
   






1a5z





















Reaction:

(S)-lactate + NAD(+) = pyruvate + Nadh.
 











(S)-lactate

+


NAD(+)

=


pyruvate

+


NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Other name(s):

L-lactic acid dehydrogenase.
L-lactic dehydrogenase.
Comments:

Also oxidizes other (S)-2-hydroxymonocarboxylic acids.
NADP(+) acts, more slowly, with the animal, but not the bacterial,
enzyme.
Links:
 
[IntEnz]  
[ExPASy]  
[KEGG]  


There are 133 PDB entries in enzyme class E.C.1.1.1.27

























































































































































































































































































































































































































  PDB code
Protein

1a5z








Lactate dehydrogenase from thermotoga maritima (tmldh)


Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(312 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1ceq






Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase.


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(304 residues)
CATH domains:
3.40.50.720
3.90.110.10

1cet






Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase.


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(305 residues)
CATH domains:
3.40.50.720
3.90.110.10

1ez4








Crystal structure of non-allosteric l-lactate dehydrogenase from lactobacillus pentosus at 2.3 angstrom resolution


Source: Lactobacillus pentosus. Organism_taxid: 1589. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1hyh








Crystal structure of l-2-hydroxyisocaproate dehydrogenase from lactobacillus confusus at 2.2 angstroms resolution-an example of strong asymmetry between subunits


Source: Weissella confusa. Organism_taxid: 1583. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: german collection of microorganisms (dsm) number dsm 20196, cell plasm


Chains:
A, B, C, D
(297 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1i0z








Human heart l-lactate dehydrogenase h chain, ternary complex with nadh and oxamate


Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Gene: ldhb. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.


Chains:
A, B
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1i10








Human muscle l-lactate dehydrogenase m chain, ternary complex with nadh and oxamate


Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Gene: ldha. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.


Chains:
A, B, C, D, E, F, G, H
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1ldb






Structure determination and refinement of bacillus stearothermophilus lactate dehydrogenase


Source: Geobacillus stearothermophilus. Organism_taxid: 1422


Chains:
A, B, C, D
(294 residues)
CATH domains:
3.40.50.720
3.90.110.10

1ldg








Plasmodium falciparum l-lactate dehydrogenase complexed with nadh and oxamate


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1ldm








Refined crystal structure of dogfish m4 apo-lactate dehydrogenase


Source: Squalus acanthias. Spiny dogfish. Organism_taxid: 7797


Chain:
A
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1ldn








Structure of a ternary complex of an allosteric lactate dehydrogenase from bacillus stearothermophilus at 2.5 angstroms resolution


Source: Geobacillus stearothermophilus. Organism_taxid: 1422


Chains:
A, B, C, D, E, F, G, H
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1llc






Structure determination of the allosteric l-lactate dehydrogenase from lactobacillus casei at 3.0 angstroms resolution


Source: Lactobacillus casei. Organism_taxid: 1582


Chain:
A
(321 residues)
CATH domains:
3.40.50.720
3.90.110.10

1lld








Molecular basis of allosteric activation of bacterial l-lactate dehydrogenase


Source: Bifidobacterium longum subsp. Longum. Organism_taxid: 1679. Strain: subsp. Longum.


Chains:
A, B
(313 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1lth








T and r states in the crystals of bacterial l-lactate dehydrogenase reveal the mechanism for allosteric control


Source: Bifidobacterium longum subsp. Longum. Organism_taxid: 1679. Strain: subsp. Longum. Gene: bifidobacterium longum ldh gene. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
T, R
(313 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1oc4








Lactate dehydrogenase from plasmodium berghei


Source: Plasmodium berghei. Organism_taxid: 5821. Strain: anka. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1pze






T.Gondii ldh1 apo form


Source: Toxoplasma gondii. Organism_taxid: 508771. Strain: me49. Gene: lactate dehydrogenase. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(323 residues)
CATH domains:
3.40.50.720
3.90.110.10

1pzf








T.Gondii ldh1 ternary complex with apad+ and oxalate


Source: Toxoplasma gondii. Organism_taxid: 5811. Gene: lactate dehydrogenase. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.00% similar to
enzyme reactant (S)-lactate

 
Het Group A3D
is 95.00% similar to
enzyme reactant NAD(+)

1pzg








T.Gondii ldh1 complexed with apad and sulfate at 1.6 angstroms


Source: Toxoplasma gondii. Organism_taxid: 508771. Strain: me49. Gene: ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group A3D
is 95.56% similar to
enzyme reactant NAD(+)

1pzh








T.Gondii ldh1 ternary complex with NAD and oxalate


Source: Toxoplasma gondii. Organism_taxid: 508771. Strain: me49. Gene: lactate dehydrogenase (ldh1). Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1sov






Toxoplasma gondii bradyzoite-specific ldh (ldh2) apo form


Source: Toxoplasma gondii. Organism_taxid: 5811. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10

1sow








T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxalate


Source: Toxoplasma gondii. Organism_taxid: 5811. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(322 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1t24








Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXQ
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1t25








Plasmodium falciparum lactate dehydrogenase complexed with nadh and 3- hydroxyisoxazole-4-carboxylic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group GAG
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1t26








Plasmodium falciparum lactate dehydrogenase complexed with nadh and 4- hydroxy-1,2,5-thiadiazole-3-carboxylic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group GBD
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1t2c








Plasmodium falciparum lactate dehydrogenase complexed with nadh


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1t2d








Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and oxalate


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1t2e








Plasmodium falciparum lactate dehydrogenase s245a, a327p mutant complexed with nadh and oxamate


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

1t2f








Human b lactate dehydrogenase complexed with NAD+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldhb. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXQ
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1u4o








Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedicarboxylic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(309 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MPD
is 40.00% similar to
enzyme reactant (S)-lactate

1u4s






Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedisulphonic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10

1u5a






Plasmodium falciparum lactate dehydrogenase complexed with 3,5- dihydroxy-2-naphthoic acid


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: lactate dehydrogenase. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(306 residues)
CATH domains:
3.40.50.720
3.90.110.10

1u5c








Plasmodium falciparum lactate dehydrogenase complexed with 3,7- dihydroxynaphthalene-2-carboxylic acid and NAD+


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(305 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1v6a






Crystal structure of l-lactate dehydrogenase from cyprinus carpio


Source: Cyprinus carpio. Common carp. Organism_taxid: 7962. Tissue: skeletal muscle


Chains:
A, B
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10

1vbi








Crystal structure of type 2 malate/lactate dehydrogenase from thermus thermophilus hb8


Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.


Chain:
A
(340 residues)
CATH domains:
1.10.1530.10
3.30.1370.60





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

1x0a








Crystal structure of type ii malate/lactate dehydrogenase from thermus thermophilus hb8


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.


Chain:
A
(344 residues)
CATH domains:
1.10.1530.10
3.30.1370.60





Bound ligand:  
Het Group FMT
is 50.00% similar to
enzyme reactant (S)-lactate

1xiv








Plasmodium falciparum lactate dehydrogenase complexed with 2-(4- chloro-[hydroxy(methoxy)methyl]cyclohexylamino)ethane-1,1,2-triol


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

1y6j






L-lactate dehydrogenase from clostridium thermocellum cth-1135


Source: Clostridium thermocellum. Organism_taxid: 1515. Atcc: 27405. Gene: cth-1135. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(289 residues)
CATH domains:
3.40.50.720
3.90.110.10

2a92








Crystal structure of lactate dehydrogenase from plasmodium vivax: complex with nadh


Source: Plasmodium vivax. Malaria parasite p. Vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

2a94








Structure of plasmodium falciparum lactate dehydrogenase complexed to apadh.


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(315 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group AP0
is 95.56% similar to
enzyme reactant NAD(+)

2aa3








Crystal structure of plasmodium vivax lactate dehydrogenase complex with apadh


Source: Plasmodium vivax. Malaria parasite p. Vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group AP0
is 95.56% similar to
enzyme reactant NAD(+)

2e37








Structure of tt0471 protein from thermus thermophilus


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.


Chains:
A, B, C, D, E, F, G, H
(308 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

2fn7








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (lactic acid) and cofactor (b- nicotinamide adenine dinucleotide)


Source: Cryptosporidium parvum. Organism_taxid: 5807. Gene: ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group LAC
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme product NADH

2ldb








Structure determination and refinement of bacillus stearothermophilus lactate dehydrogenase


Source: Geobacillus stearothermophilus. Organism_taxid: 1422


Chains:
A, B, C, D
(301 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

2ldx






Characterization of the antigenic sites on the refined 3- angstroms resolution structure of mouse testicular lactate dehydrogenase c4


Source: Mus musculus. House mouse. Organism_taxid: 10090


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10

2v65






Apo ldh from the psychrophilE C. Gunnari


Source: Champsocephalus gunnari. Mackerel icefish. Organism_taxid: 52237. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B
(326 residues)
CATH domains:
3.40.50.720
3.90.110.10

2v6b






Crystal structure of lactate dehydrogenase from deinococcus radiodurans (apo form)


Source: Deinococcus radiodurans. Organism_taxid: 1299. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(274 residues)
CATH domains:
3.40.50.720
3.90.110.10

2v6m






Crystal structure of lactate dehydrogenase from thermus thermophilus hb8 (apo form)


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10

2v7p








Crystal structure of lactate dehydrogenase from thermus thermophilus hb8 (holo form)


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

2x8l








Plasmodium falciparum lactate dehydrogenase apo structure


Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: malaria parasite


Chain:
A
(311 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

2xxb








Penta-mutant of thermus thermophilus lactate dehydrogenase, complex with amp


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group AMP
is 52.00% similar to
enzyme reactant NAD(+)

2xxj








Penta mutant of lactate dehydrogenase from thermus thermophilus, ternary complex


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: dh5alpha.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

2zqy






T-state structure of allosteric l-lactate dehydrogenase from lactobacillus casei


Source: Lactobacillus casei. Organism_taxid: 1582. Strain: iam 12473. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(305 residues)
CATH domains:
3.40.50.720
3.90.110.10

2zqz






R-state structure of allosteric l-lactate dehydrogenase from lactobacillus casei


Source: Lactobacillus casei. Organism_taxid: 1582. Strain: iam 12473. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D, E, F
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10

3czm








T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxq


Source: Toxoplasma gondii. Organism_taxid: 5811. Gene: lactate dehydrogenase. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(322 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXQ
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3d0o






Crystal structure of lactate dehydrogenase from staphylococcus aureus


Source: Staphylococcus aureus. Organism_taxid: 93062. Strain: col. Gene: ldh1, sacol0222. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(309 residues)
CATH domains:
3.40.50.720
3.90.110.10

3d4p








Crystal structure of lactate dehydrogenase from staphylococcus aureus complexed with NAD and pyruvate


Source: Staphylococcus aureus subsp. Aureus col. Organism_taxid: 93062. Gene: ldh1, sacol0222. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3h3f








Rabbit muscle l-lactate dehydrogenase in complex with nadh and oxamate


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Other_details: muscle


Chains:
A, B, C, D, E, F, G, H
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

3h3j








Crystal structure of lactate dehydrogenase mutant (a85r) from staphylococcus aureus complexed with NAD and pyruvate


Source: Staphylococcus aureus subsp. Aureus col. Organism_taxid: 93062. Gene: ldh1, sacol0222. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(313 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3ldh








A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes


Source: Squalus acanthias. Spiny dogfish. Organism_taxid: 7797


Chain:
A
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3om9








T. Gondii bradyzoite-specific ldh (ldh1) in complex with NAD and oxq


Source: Toxoplasma gondii. Organism_taxid: 5811. Gene: lactate dehydrogenase, tggt1_115280. Expressed in: escherichia coli. Expression_system_taxid: 511693.


Chains:
A, B, C, D
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXQ
is 50.00% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3pqd








Crystal structure of l-lactate dehydrogenase from bacillus subtilis complexed with fbp and NAD+


Source: Bacillus subtilis. Organism_taxid: 1423. Gene: ldh, lcte, bsu03050. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B, C, D, E, F, G, H
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3pqe






Crystal structure of l-lactate dehydrogenase from bacillus subtilis with h171c mutation


Source: Bacillus subtilis. Organism_taxid: 1423. Gene: ldh, lcte, bsu03050. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B, C, D
(314 residues)
CATH domains:
3.40.50.720
3.90.110.10

3pqf








Crystal structure of l-lactate dehydrogenase from bacillus subtilis mutation h171c complexed with NAD+


Source: Bacillus subtilis. Organism_taxid: 1423. Gene: ldh, lcte, bsu03050. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B, C, D
(314 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3vku






Penta mutant of lactobacillus casei lactate dehydrogenase


Source: Lactobacillus casei. Organism_taxid: 1582. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F
(290 residues)
CATH domains:
3.40.50.720
3.90.110.10

3vkv






Complex structure of lactobacillus casei lactate dehydrogenase with fructose-1,6-bisphosphate


Source: Lactobacillus casei. Organism_taxid: 1582. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F
(307 residues)
CATH domains:
3.40.50.720
3.90.110.10

3vpf








Complex structure of lactobacillus casei lactate dehydrogenase penta mutant with pyruvate


Source: Lactobacillus casei. Organism_taxid: 1582. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F
(306 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

3vpg








L-lactate dehydrogenase from thermus caldophilus gk24


Source: Thermus caldophilus. Organism_taxid: 272. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

3vph








L-lactate dehydrogenase from thermus caldophilus gk24 complexed with oxamate, nadh and fbp


Source: Thermus caldophilus. Organism_taxid: 272. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3wsv








Crystal structure of minor l-lactate dehydrogenase from enterococcus mundtii in the ligands-unbound form


Source: Enterococcus mundtii. Organism_taxid: 53346. Strain: 15-1a. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(312 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

3wsw








Crystal structure of minor l-lactate dehydrogenase from enterococcus mundtii in the ligands-bound form


Source: Enterococcus mundtii. Organism_taxid: 53346. Strain: 15-1a. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

3zh2






Structure of plasmodium falciparum lactate dehydrogenase in complex with a DNA aptamer


Source: Plasmodium falciparum. Organism_taxid: 36329. Strain: 3d7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630


Chains:
A, B, C, D
(314 residues)
CATH domains:
3.40.50.720
3.90.110.10

3zzn








5-mutant (r79w, r151a, e279a, e299a,e313a) lactate-dehydrogenase from thermus thermophillus


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 668369.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group ADP
is 61.36% similar to
enzyme reactant NAD(+)

4a73






Single point mutant of thermus thermophilus lactate dehydrogenase


Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 668369.


Chains:
A, B, C, D
(310 residues)
CATH domains:
3.40.50.720
3.90.110.10

4aj1








Rat ldha in complex with n-(2-(methylamino)-1,3- benzothiazol-6-yl)acetamide


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4aj2








Rat ldha in complex with 5-(2-chlorophenyl)-1h-tetrazole


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(327 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4aj4








Rat ldha in complex with 4-((2-allylsulfanyl-1,3-benzothizol-6-yl) amino)-4-oxo-butanoic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MLI
is 62.50% similar to
enzyme reactant (S)-lactate

4aje








Rat ldha in complex with 2-(4-bromophenoxy)propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(327 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group 2B4
is 40.00% similar to
enzyme reactant (S)-lactate

4ajh








Rat ldha in complex with n-(2-methyl-1,3-benzothiazol-6-yl)-3-ureido- propanamide and 2-(4-bromophenoxy)propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group 2B4
is 40.00% similar to
enzyme reactant (S)-lactate

4aji






Rat ldha in complex with 2-((3,4-dimethoxyphenyl)methyl)) propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(327 residues)
CATH domains:
3.40.50.720
3.90.110.10

4ajj








Rat ldha in complex with 2-((3,4-dimethoxyphenyl)methyl)) propanedioic acid and n-(2-methyl-1,3-benzothiazol-6-yl)-3- ureido-propanamide


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MLI
is 62.50% similar to
enzyme reactant (S)-lactate

4ajk








Rat ldha in complex with n-(2-(methylamino)-1,3-benzothiazol-6-yl) acetamide


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MLI
is 62.50% similar to
enzyme reactant (S)-lactate

4ajl








Rat ldha in complex with 3-(ethylcarbamoylamino)-n-(2-methyl-1,3- benzothiazol-6-yl)propanamide


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(328 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4ajn








Rat ldha in complex with 2-((4-(2-((3-((2-methyl-1,3- benzothiazol-6-yl)amino)-3-oxo-propyl)carbamoylamino)ethyl) phenyl)methyl)propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4ajo








Rat ldha in complex with 2-((4-(4-((3-((2-methyl-1,3- benzothiazol-6yl)amino)-3-oxo-propyl)amino)-4-oxo-butyl) phenyl)methyl)propanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4ajp








Human ldha in complex with 2-((4-(4-((3-((2-methyl-1,3- benzothiazol-6yl)amino)-3-oxo-propyl)amino)-4-oxo-butyl) phenyl)methyl)propanedioic acid


Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(329 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4al4








Rat ldha in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)3-oxo-propyl)carbamoylamino)ethoxy) phenyl) methylpropanedioic acid


Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.


Chains:
A, B, C, D
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4b7u








Plasmodium falciparum l-lactate dehydrogenase complexed with bicine


Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(316 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MPD
is 40.00% similar to
enzyme reactant (S)-lactate

4i8x






Crystal structure of rabbit ldha in complex with ap27460


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D, E, F, G, H
(321 residues)
CATH domains:
3.40.50.720
3.90.110.10

4i9h






Crystal structure of rabbit ldha in complex with ap28669


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D, E, F, G, H
(325 residues)
CATH domains:
3.40.50.720
3.90.110.10

4i9n






Crystal structure of rabbit ldha in complex with ap28161 and ap28122


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D, E, F, G, H
(324 residues)
CATH domains:
3.40.50.720
3.90.110.10

4i9u






Crystal structure of rabbit ldha in complex with a fragment inhibitor ap26256


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D, E, F, G, H
(323 residues)
CATH domains:
3.40.50.720
3.90.110.10

4jnk








Lactate dehydrogenase a in complex with inhibitor compound 22


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(326 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group LAC
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4l4r






Structural characterisation of the apo-form of human lactate dehydrogenase m isozyme


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, H
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10

4l4s








Structural characterisation of the nadh binary complex of human lactate dehydrogenase m isozyme


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
H, A
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4lmr






Crystal structure of l-lactate dehydrogenase from bacillus cereus atcc 14579, nysgrc target 029452


Source: Bacillus cereus. Organism_taxid: 226900. Strain: atcc 14579. Gene: bc_1924, ldh, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B
(312 residues)
CATH domains:
3.40.50.720
3.90.110.10

4ln1






Crystal structure of l-lactate dehydrogenase from bacillus cereus atcc 14579 complexed with calcium, nysgrc target 029452


Source: Bacillus cereus. Organism_taxid: 226900. Strain: atcc 14579. Gene: bc_1924, ldh, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B, C, D
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10

4m1q








Crystal structure of l-lactate dehydrogenase from bacillus selenitireducens mls10, nysgrc target 029814.


Source: Bacillus selenitireducens. Organism_taxid: 439292. Strain: mls10. Gene: ldh, bsel_2311. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chains:
A, B
(312 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group MPD
is 40.00% similar to
enzyme reactant (S)-lactate

4m49








Lactate dehydrogenase a in complex with a substituted pyrazine inhibitor compound 18


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group LAC
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4nd1








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with cofactor (b-nicotinamide adenine dinucleotide) and inhibitor (oxamic acid)


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

4nd2








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (pyruvic acid) and cofactor analog (3-acetylpyridine adenine dinucleotide)


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group A3D
is 95.56% similar to
enzyme reactant NAD(+)

4nd3








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (l-lactic acid) and cofactor (b- nicotinamide adenine dinucleotide)


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group 2OP
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

4nd4








Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (pyruvic acid) and cofactor (b- nicotinamide adenine dinucleotide)


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(317 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group PYR
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

4nd5






Crystal structure of the lactate dehydrogenase from cryptosporidium parvum


Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd7_480, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B, C, D
(302 residues)
CATH domains:
3.40.50.720
3.90.110.10

4ojn








Crystal structure of human muscle l-lactate dehydrogenase


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F, G, H
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group GOL
is 71.43% similar to
enzyme reactant (S)-lactate

4okn








Crystal structure of human muscle l-lactate dehydrogenase, ternary complex with nadh and oxalate


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F, G, H
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXL
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4plz








Crystal structure of plasmodium falciparum lactate dehydrogenase mutant w107fa.


Source: Plasmodium falciparum. Organism_taxid: 5833. Gene: ldh-p, ldh, ldh. Expressed in: escherichia coli. Expression_system_taxid: 469008.


Chain:
A
(302 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4qo7








Lactate dehydrogenase a in complex with substituted 3-hydroxy-2- mercaptocyclohex-2-enone compound 7


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group 2OP
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4qo8








Lactate dehydrogenase a in complex with substituted 3-hydroxy-2- mercaptocyclohex-2-enone compound 104


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group LAC
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4qsm






Crystal structure of human muscle l-lactate dehydrogenase in complex with inhibitor 2, 3-[7-(2,4-dimethoxypyrimidin-5-yl)-3- sulfamoylquinolin-4-yl]aminobenzoic acid


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F, G, H
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10

4qt0






Crystal structure of human muscle l-lactate dehydrogenase in complex with inhibitor 1, 3-[3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl) quinolin-4-yl]aminobenzoic acid


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D, E, F, G, H
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10

4r68








Lactate dehydrogenase in complex with inhibitor compound 31


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4r69








Lactate dehydrogenase in complex with inhibitor compound 13


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(325 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4rls








Lactate dehydrogenase in complex with inhibitor compound 47


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group 2OP
corresponds to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4uul






Apo trichomonas vaginalis lactate dehydrogenase l91r


Source: Trichomonas vaginalis. Organism_taxid: 5722. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(334 residues)

4uum






Apo trichomonas vaginalis lactate dehydrogenase


Source: Trichomonas vaginalis. Organism_taxid: 5722. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B
(334 residues)

4uun








Trichomonas vaginalis lactate dehydrogenase in complex with nadh


Source: Trichomonas vaginalis. Organism_taxid: 5722. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, B
(335 residues)





Bound ligand:  
Het Group NAI
corresponds to
enzyme reactant NAD(+)

4zvv








Lactate dehydrogenase a in complex with a trisubstituted piperidine-2, 4-dione inhibitor gne-140


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

5a1t








Trichomonas vaginalis lactate dehydrogenase in complex with nadh and oxamate


Source: Trichomonas vaginalis. Organism_taxid: 5722. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B
(331 residues)







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

5es3








Co-crystal structure of ldh liganded with oxamate


Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: ldha, ldh-1, ldh1. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chains:
A, C, E, F, D, H, B, G
(328 residues)





Bound ligand:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

5hru






Crystal structure of plasmodium vivax ldh in complex with a DNA aptamer called pl1


Source: Plasmodium vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Phylica emirnensis. Organism_taxid: 178505


Chains:
A, B
(305 residues)

5hs4






Plasmdoium vivax lactate dehydrogenase


Source: Plasmodium vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562.


Chain:
A
(301 residues)

5hto






Crystal structure of plasmodium vivax ldh in complex with a DNA aptamer called pl1 (tetrameric ldh in an asymmetric unit)


Source: Plasmodium vivax. Organism_taxid: 5855. Gene: ldh. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 5855


Chains:
A, B, D, E
(302 residues)

5ixs








Lactate dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6r)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6- (thiophen-3-yl)-5,6-dihydropyridin-2(1h)-one


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(327 residues)





Bound ligand:  
Het Group TXD
corresponds to
enzyme reactant NAD(+)

5ixy








Lactate dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~s)-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4- oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one


Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)





Bound ligand:  
Het Group NAD
corresponds to
enzyme reactant NAD(+)

5k0z






Cryo-em structure of lactate dehydrogenase (ldh) in inhibitor-bound state


Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ldhb. Expressed in: bacteria. Expression_system_taxid: 2


Chains:
A, B, C, D
(317 residues)

5kkc








L-lactate dehydrogenase from rabbit muscle with the inhibitor 6dhnad


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986


Chains:
A, B, C, D
(328 residues)





Bound ligand:  
Het Group 6V0
corresponds to
enzyme reactant NAD(+)

5ldh








Structure of the active ternary complex of pig heart lactate dehydrogenase with s-lac-NAD at 2.7 angstroms resolution


Source: Sus scrofa. Pig. Organism_taxid: 9823


Chains:
A, B
(334 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group CIT
is 46.15% similar to
enzyme reactant (S)-lactate

 
Het Group LNC
is 86.27% similar to
enzyme product NADH

5nqb








Rabbit muscle l-lactate dehydrogenase in complex with malonate


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Gene: ldha. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)





Bound ligand:  
Het Group MLI
is 62.50% similar to
enzyme reactant (S)-lactate

5nqq








Rabbit muscle l-lactate dehydrogenase in complex with nadh and oxaloacetate


Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Gene: ldha. Expressed in: escherichia coli. Expression_system_taxid: 562


Chains:
A, B, C, D
(331 residues)







Bound ligands:  
Het Group OAA
is 66.67% similar to
enzyme reactant (S)-lactate

 
Het Group NAI
corresponds to
enzyme reactant NAD(+)

6ldh






Refined crystal structure of dogfish m4 apo-lactate dehydrogenase


Source: Squalus acanthias. Spiny dogfish. Organism_taxid: 7797


Chain:
A
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10

8ldh








Refined crystal structure of dogfish m4 apo-lactate dehydrogenase


Source: Squalus acanthias. Spiny dogfish. Organism_taxid: 7797


Chain:
A
(330 residues)
CATH domains:
3.40.50.720
3.90.110.10





Bound ligand:  
Het Group CIT
is 46.15% similar to
enzyme reactant (S)-lactate

9ldb








Design and synthesis of new enzymes based on the lactate dehydrogenase framework


Source: Sus scrofa. Pig. Organism_taxid: 9823


Chains:
A, B
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)

9ldt








Design and synthesis of new enzymes based on the lactate dehydrogenase framework


Source: Sus scrofa. Pig. Organism_taxid: 9823


Chains:
A, B
(332 residues)
CATH domains:
3.40.50.720
3.90.110.10







Bound ligands:  
Het Group OXM
is 71.43% similar to
enzyme reactant (S)-lactate

 
Het Group NAD
corresponds to
enzyme reactant NAD(+)
-

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