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What determines the direction in which motor proteins go?
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What determines the direction in which motor proteins go?
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$begingroup$
I know that kinesin motor proteins move towards the positive (beta) end of the microtubule, while dyenin motor proteins move towards the negative (alpha) end of the microtubule. However, because the microtubule is composed of repeating alpha and beta units in ABABABABAB fashion (as shown in the picture below), what causes motor proteins to move to the positive rather than the negative pole?
For example, if one "leg" of the kinesin is bound to a beta tubulin while the other leg is up and ready to bind again, what determines which alpha tubulin it binds to (since there is alpha in front and in back of the beta tubilin it is bound to)?
protein-binding intracellular-transport
edited 5 hours ago
David
13.3k42458
asked 8 hours ago
F16FalconF16Falcon
1975
$endgroup$
add a comment |
$begingroup$
I know that kinesin motor proteins move towards the positive (beta) end of the microtubule, while dyenin motor proteins move towards the negative (alpha) end of the microtubule. However, because the microtubule is composed of repeating alpha and beta units in ABABABABAB fashion (as shown in the picture below), what causes motor proteins to move to the positive rather than the negative pole?
For example, if one "leg" of the kinesin is bound to a beta tubulin while the other leg is up and ready to bind again, what determines which alpha tubulin it binds to (since there is alpha in front and in back of the beta tubilin it is bound to)?
protein-binding intracellular-transport
edited 5 hours ago
David
13.3k42458
asked 8 hours ago
F16FalconF16Falcon
1975
$endgroup$
1
$begingroup$
I have edited your question to remove the anthropomorphic implications of using “know” with inanimate objects.
$endgroup$
– David
5 hours ago
$begingroup$
@David I appreciate it, I will keep this in mind for future questions!
$endgroup$
– F16Falcon
1 hour ago
add a comment |
$begingroup$
I know that kinesin motor proteins move towards the positive (beta) end of the microtubule, while dyenin motor proteins move towards the negative (alpha) end of the microtubule. However, because the microtubule is composed of repeating alpha and beta units in ABABABABAB fashion (as shown in the picture below), what causes motor proteins to move to the positive rather than the negative pole?
For example, if one "leg" of the kinesin is bound to a beta tubulin while the other leg is up and ready to bind again, what determines which alpha tubulin it binds to (since there is alpha in front and in back of the beta tubilin it is bound to)?
protein-binding intracellular-transport
edited 5 hours ago
David
13.3k42458
asked 8 hours ago
F16FalconF16Falcon
1975
$endgroup$
I know that kinesin motor proteins move towards the positive (beta) end of the microtubule, while dyenin motor proteins move towards the negative (alpha) end of the microtubule. However, because the microtubule is composed of repeating alpha and beta units in ABABABABAB fashion (as shown in the picture below), what causes motor proteins to move to the positive rather than the negative pole?
For example, if one "leg" of the kinesin is bound to a beta tubulin while the other leg is up and ready to bind again, what determines which alpha tubulin it binds to (since there is alpha in front and in back of the beta tubilin it is bound to)?
protein-binding intracellular-transport
protein-binding intracellular-transport
edited 5 hours ago
David
13.3k42458
asked 8 hours ago
F16FalconF16Falcon
1975
edited 5 hours ago
David
13.3k42458
asked 8 hours ago
F16FalconF16Falcon
1975
edited 5 hours ago
David
13.3k42458
edited 5 hours ago
David
13.3k42458
edited 5 hours ago
David
13.3k42458
13.3k42458
asked 8 hours ago
F16FalconF16Falcon
1975
asked 8 hours ago
F16FalconF16Falcon
1975
asked 8 hours ago
F16FalconF16Falcon
1975
1975
1
$begingroup$
I have edited your question to remove the anthropomorphic implications of using “know” with inanimate objects.
$endgroup$
– David
5 hours ago
$begingroup$
@David I appreciate it, I will keep this in mind for future questions!
$endgroup$
– F16Falcon
1 hour ago
add a comment |
1
$begingroup$
I have edited your question to remove the anthropomorphic implications of using “know” with inanimate objects.
$endgroup$
– David
5 hours ago
$begingroup$
@David I appreciate it, I will keep this in mind for future questions!
$endgroup$
– F16Falcon
1 hour ago
1
1
$begingroup$
I have edited your question to remove the anthropomorphic implications of using “know” with inanimate objects.
$endgroup$
– David
5 hours ago
$begingroup$
I have edited your question to remove the anthropomorphic implications of using “know” with inanimate objects.
$endgroup$
– David
5 hours ago
$begingroup$
@David I appreciate it, I will keep this in mind for future questions!
$endgroup$
– F16Falcon
1 hour ago
$begingroup$
@David I appreciate it, I will keep this in mind for future questions!
$endgroup$
– F16Falcon
1 hour ago
add a comment |
1 Answer
1
active
oldest
votes
$begingroup$
While you're entirely correct that the ABABAB sequence is symmetric to a motor protein cruising along, the individual $alpha$ and $beta$ monomers themselves are not symmetric along the axis of movement (or any axis at all, as far as I can tell). This produces a polarity that can be seen in the figure below, from the original 1998 paper describing it.
The figure you use above to display the microtubule is slightly misleading in this way; it shows the subunits as blobby spheres. However, the motor proteins are able to distinguish the top of these molecules from the bottom, seeking a unique set of loops and helices to attach to. As it walks, then, the motor protein can only bind to one side (pole) of the subunit and is unable to walk backwards.
answered 6 hours ago
DubukayDubukay
550112
$endgroup$
$begingroup$
Ah, that makes sense; the protein subunits aren't symmetrical so the motor proteins are able to distinguish between the two adjacent tubulins, to determine which direction to go. Very well explained, even my professor didn't have an explanation!
$endgroup$
– F16Falcon
1 hour ago
add a comment |
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1 Answer
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oldest
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1 Answer
1
active
oldest
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active
oldest
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active
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votes
$begingroup$
While you're entirely correct that the ABABAB sequence is symmetric to a motor protein cruising along, the individual $alpha$ and $beta$ monomers themselves are not symmetric along the axis of movement (or any axis at all, as far as I can tell). This produces a polarity that can be seen in the figure below, from the original 1998 paper describing it.
The figure you use above to display the microtubule is slightly misleading in this way; it shows the subunits as blobby spheres. However, the motor proteins are able to distinguish the top of these molecules from the bottom, seeking a unique set of loops and helices to attach to. As it walks, then, the motor protein can only bind to one side (pole) of the subunit and is unable to walk backwards.
answered 6 hours ago
DubukayDubukay
550112
$endgroup$
$begingroup$
Ah, that makes sense; the protein subunits aren't symmetrical so the motor proteins are able to distinguish between the two adjacent tubulins, to determine which direction to go. Very well explained, even my professor didn't have an explanation!
$endgroup$
– F16Falcon
1 hour ago
add a comment |
$begingroup$
While you're entirely correct that the ABABAB sequence is symmetric to a motor protein cruising along, the individual $alpha$ and $beta$ monomers themselves are not symmetric along the axis of movement (or any axis at all, as far as I can tell). This produces a polarity that can be seen in the figure below, from the original 1998 paper describing it.
The figure you use above to display the microtubule is slightly misleading in this way; it shows the subunits as blobby spheres. However, the motor proteins are able to distinguish the top of these molecules from the bottom, seeking a unique set of loops and helices to attach to. As it walks, then, the motor protein can only bind to one side (pole) of the subunit and is unable to walk backwards.
answered 6 hours ago
DubukayDubukay
550112
$endgroup$
$begingroup$
Ah, that makes sense; the protein subunits aren't symmetrical so the motor proteins are able to distinguish between the two adjacent tubulins, to determine which direction to go. Very well explained, even my professor didn't have an explanation!
$endgroup$
– F16Falcon
1 hour ago
add a comment |
$begingroup$
While you're entirely correct that the ABABAB sequence is symmetric to a motor protein cruising along, the individual $alpha$ and $beta$ monomers themselves are not symmetric along the axis of movement (or any axis at all, as far as I can tell). This produces a polarity that can be seen in the figure below, from the original 1998 paper describing it.
The figure you use above to display the microtubule is slightly misleading in this way; it shows the subunits as blobby spheres. However, the motor proteins are able to distinguish the top of these molecules from the bottom, seeking a unique set of loops and helices to attach to. As it walks, then, the motor protein can only bind to one side (pole) of the subunit and is unable to walk backwards.
answered 6 hours ago
DubukayDubukay
550112
$endgroup$
While you're entirely correct that the ABABAB sequence is symmetric to a motor protein cruising along, the individual $alpha$ and $beta$ monomers themselves are not symmetric along the axis of movement (or any axis at all, as far as I can tell). This produces a polarity that can be seen in the figure below, from the original 1998 paper describing it.
The figure you use above to display the microtubule is slightly misleading in this way; it shows the subunits as blobby spheres. However, the motor proteins are able to distinguish the top of these molecules from the bottom, seeking a unique set of loops and helices to attach to. As it walks, then, the motor protein can only bind to one side (pole) of the subunit and is unable to walk backwards.
answered 6 hours ago
DubukayDubukay
550112
answered 6 hours ago
DubukayDubukay
550112
answered 6 hours ago
DubukayDubukay
550112
answered 6 hours ago
DubukayDubukay
550112
550112
$begingroup$
Ah, that makes sense; the protein subunits aren't symmetrical so the motor proteins are able to distinguish between the two adjacent tubulins, to determine which direction to go. Very well explained, even my professor didn't have an explanation!
$endgroup$
– F16Falcon
1 hour ago
add a comment |
$begingroup$
Ah, that makes sense; the protein subunits aren't symmetrical so the motor proteins are able to distinguish between the two adjacent tubulins, to determine which direction to go. Very well explained, even my professor didn't have an explanation!
$endgroup$
– F16Falcon
1 hour ago
$begingroup$
Ah, that makes sense; the protein subunits aren't symmetrical so the motor proteins are able to distinguish between the two adjacent tubulins, to determine which direction to go. Very well explained, even my professor didn't have an explanation!
$endgroup$
– F16Falcon
1 hour ago
$begingroup$
Ah, that makes sense; the protein subunits aren't symmetrical so the motor proteins are able to distinguish between the two adjacent tubulins, to determine which direction to go. Very well explained, even my professor didn't have an explanation!
$endgroup$
– F16Falcon
1 hour ago
add a comment |
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$begingroup$
I have edited your question to remove the anthropomorphic implications of using “know” with inanimate objects.
$endgroup$
– David
5 hours ago
$begingroup$
@David I appreciate it, I will keep this in mind for future questions!
$endgroup$
– F16Falcon
1 hour ago